fgls: Feasible Generalized Least Squares

In fassoc: VARIANCE COMPONENT BASED MULTI-MARKER ASSOCIATION TEST USING FAMILY AND UNRELATED DATA

Description

The function is based on the same function in "MixABEL" package. It performs marker set based association based on the Feasible Generalized Least Squares (FGLS) model.

Usage

fgls(Tped, n1, n2)

Arguments

Tped	Pedigree data matrix. The first six columns are the Family ID (FID), Inidvidual ID (IID), Paternal ID (FAT), Maternal ID (MAT), Sex (SEX), Phenotype (pheno), respectively. SNP genotypes (column 7 onwards) are coded 0/1/2 (minor allele count).
n1	Number of nuclear families.
n2	Nunber of unrelated individuals.

Value

Returns p-value

Author(s)

Xuefeng Wang

References

Li et al. 2011. A rapid generalized least squares model for a genome-wide quantitative trait association analysis in families. Hum Hered. 71:67-82.

See Also

vc.score

Examples

		fgls(Tped,100,400)

fassoc documentation built on May 2, 2019, 4:53 p.m.