ped.simu: Simulation Function

In fassoc: VARIANCE COMPONENT BASED MULTI-MARKER ASSOCIATION TEST USING FAMILY AND UNRELATED DATA

Description

This function simulates both phenotypes and genotypes of a combination of family and unreated data.

Usage

ped.simu(hap = hap, pos = pos, nfa = 100, nun = 400, h2 = 0.03,
           rfreq = 0.02, hrisk = 0.1)

Arguments

hap	Haplotype information.
pos	Anotated position information.
nfa	Number of nulcear families.
nun	Number of unrelated individuals
h2	The proportion of variation that can be explained by the simualted genetic region.
rfreq	The rare variants threshold of MAF used in the simulation
hrisk	The proportion of risk haplotypes in the haplotype pool.

Value

It returns a pedigree matrix ready for use by functions vc.score and fgls in this package.

Author(s)

Xuefeng Wang

References

T Feng, RC Elston and X Zhu. 2011. Detecting rare and common variants for complex traits: sibpair and odds ratio weighted sum statistics (SPWSS, ORWSS). Genet Epidemiol, 35: 398-409.

See Also

vc.score

Examples

		Tped<-ped.simu(hap,pos,h2=0.02)
		vc.score(Tped,100,400)
		fgls(Tped,100,400)	

fassoc documentation built on May 2, 2019, 4:53 p.m.