phase2genotype: phase2genotype

In AllelicImbalance: Investigates Allele Specific Expression

Description

Convert the phase from the internally stored phase, ref and alt information

Usage

phase2genotype(x, ...)

## S4 method for signature 'array'
phase2genotype(x, ref, alt, return.class = "matrix", ...)

Arguments

x	array see examples
...	pass on additional param
ref	reference allele vector
alt	alternative allele vector
return.class	'matrix' or 'array'

Details

To not introduce redundant information in the ASEset object, the genotype matrix is accessed from the phase matrix, which together with ref and alt allele information contains the same information(not taken into account three-allelic or more SNPs).

The genotype matrix retrieved from an ASEset object can differ from the genotype matrix stored in the object if reference and alternative alleles were not used or has changed since the phase genotype matrix was stored. Basically, it is preferable to provide reference and alternative information when storing the genotype matrix.

If possible, it is better to not use a genotype matrix, but instead relying completely on storing a phase matrix(or array) together with reference and alternative allele information.

Author(s)

Jesper R. Gadin, Lasse Folkersen

Examples

#load example data
data(ASEset)
data(genomatrix)
p <- genotype2phase(genomatrix, ref(ASEset), return.class="array")
ref <- ref(ASEset)
alt <- inferAltAllele(ASEset)

gt <- phase2genotype(p, ref, alt, return.class="matrix")

AllelicImbalance documentation built on Nov. 8, 2020, 6:52 p.m.