MMAPPR2: Mutation Mapping Analysis Pipeline for Pooled RNA-Seq

MMAPPR2 maps mutations resulting from pooled RNA-seq data from the F2 cross of forward genetic screens. Its predecessor is described in a paper published in Genome Research (Hill et al. 2013). MMAPPR2 accepts aligned BAM files as well as a reference genome as input, identifies loci of high sequence disparity between the control and mutant RNA sequences, predicts variant effects using Ensembl's Variant Effect Predictor, and outputs a ranked list of candidate mutations.

Package details

AuthorKyle Johnsen [aut], Nathaniel Jenkins [aut], Jonathon Hill [cre]
Bioconductor views DNASeq PooledScreens RNASeq VariantDetection
MaintainerJonathon Hill <>
Package repositoryView on Bioconductor
Installation Install the latest version of this package by entering the following in R:
if (!requireNamespace("BiocManager", quietly = TRUE))


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MMAPPR2 documentation built on Nov. 8, 2020, 6:53 p.m.