Call wide peaks for sequencing data
Nucleoli serve as major organizing hubs for the three-dimensional structure of mammalian heterochromatin. Specific loci, termed nucleolar-associated domains (NADs), form frequent three-dimensional associations with nucleoli. Early mammalian development is a critical period to study NAD biological function, because interactions between pericentromeric chromatin and perinucleolar regions are particularly dynamic during embryonic development . We therefore propose for the first time to map the NADs in the mouse genome, determine how these associations are altered during embryonic stem cell (ESC) differentiation, and develop tools for study of these higher-order chromosome interactions in fixed and live single cells.
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The peaks are wide peaks (over 10K bps) and the chromosomes were acrocentric.
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