SPIA: Signaling Pathway Impact Analysis (SPIA) using combined evidence of pathway over-representation and unusual signaling perturbations

This package implements the Signaling Pathway Impact Analysis (SPIA) which uses the information form a list of differentially expressed genes and their log fold changes together with signaling pathways topology, in order to identify the pathways most relevant to the condition under the study.

Getting started

Package details

AuthorAdi Laurentiu Tarca <atarca@med.wayne.edu>, Purvesh Kathri <purvesh@cs.wayne.edu> and Sorin Draghici <sorin@wayne.edu>
Bioconductor views GraphAndNetwork Microarray
MaintainerAdi Laurentiu Tarca <atarca@med.wayne.edu>
Licensefile LICENSE
URL http://bioinformatics.oxfordjournals.org/cgi/reprint/btn577v1
Package repositoryView on Bioconductor
Installation Install the latest version of this package by entering the following in R:
if (!requireNamespace("BiocManager", quietly = TRUE))


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SPIA documentation built on Nov. 8, 2020, 5:44 p.m.