annotateNearest: Annotate the results of nearest

In bumphunter: Bump Hunter

Description

Annotate the results of nearest with more information about the type of match.

Usage

annotateNearest(x, subject, annotate = TRUE, ...)

Arguments

x	The query. An IRanges or GenomicRanges object, or a data.frame with columns for start, end, and, optionally, chr or seqnames.
subject	The subject. An IRanges or GenomicRanges object, or a data.frame with columns for start, end, and, optionally, chr or seqnames.
annotate	Whether to annotate the result.
...	Arguments passed along to nearest.

Details

This function runs nearest and then annotates the nearest hit. Note that the nearest subject range to a given query may not be unique and we arbitrarily chose one as done by default by nearest.

Value

A data frame with columns c("distance", "subjectHits", "type", "amountOverlap", "insideDistamce", "size1", "size2") unless annotate is FALSE, in which case only the first two columns are returned as an integer matrix.

dist	Signed distance to the nearest target. Queries downstream from (i.e. past) their nearest target are given a negative distance.
subjectHits	The index of the nearest target.
type	one of c("inside", "cover", "disjoint", "overlap").
amountOverlap	The width of the overlap region, if any.
insideDistance	When a query is contained in its nearest target, the signed minimum of the two distances target-start-to-query-start and query-end-to-target-end. The former is taken positive, and the latter, which wins in ties, negative. dist will be 0 in this case.
size1	equals width(x).
size2	equals width(subject).

Author(s)

Harris Jaffee, Peter Murakami and Rafael A. Irizarry

See Also

nearest, matchGenes

Examples

query <- GRanges(seqnames = 'chr1', IRanges(c(1, 4, 9), c(5, 7, 10)))
subject <- GRanges('chr1', IRanges(c(2, 2, 10), c(2, 3, 12)))
nearest(query, subject)
distanceToNearest(query, subject)

## showing 'cover' and 'disjoint', and 'amountOverlap'
annotateNearest(query, subject)

## showing 'inside' and 'insideDist', and 'amountOverlap'
annotateNearest(subject, query)
annotateNearest(GRanges('chr1', IRanges(3,3)), GRanges('chr1', IRanges(2,5)))
annotateNearest(GRanges('chr1', IRanges(3,4)), GRanges('chr1', IRanges(2,5)))
annotateNearest(GRanges('chr1', IRanges(4,4)), GRanges('chr1', IRanges(2,5)))

bumphunter documentation built on Nov. 8, 2020, 4:59 p.m.