getGraphEntryGenes: Extract all the possible entry point (genes with no entering...

Description Usage Arguments Value References Examples

View source: R/getGraphEntryGenes.R

Description

It extracts the possible entry point of the graph. Entry points are defined as nodes with no entering edges.

Usage

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getGraphEntryGenes(graph, byCliques=FALSE, root=NULL)

Arguments

graph

a graphNEL object.

byCliques

when TRUE it returns a list where entry point are organized by cliques.

root

nodes by which rip ordering is performed (as far as possible) on the variables using the maximum cardinality search algorithm.

Value

a vector of gene names representing the entry point of graph.

References

Martini P, Sales G, Massa MS, Chiogna M, Romualdi C. Along signal paths: an empirical gene set approach exploiting pathway topology. NAR. 2012 Sep.

Massa MS, Chiogna M, Romualdi C. Gene set analysis exploiting the topology of a pathway. BMC System Biol. 2010 Sep 1;4:121.

Examples

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if (require(graphite)) {
  kegg  <- pathways("hsapiens", "kegg")
  graph <- pathwayGraph(convertIdentifiers(kegg$'Chronic myeloid leukemia', "entrez"))
  getGraphEntryGenes(graph)
}

clipper documentation built on Nov. 8, 2020, 6:18 p.m.