Sun_topology: Sun's topology measure of disease similarity calculating

Description Usage Arguments Value Author(s) References Examples

View source: R/Sun.R

Description

given two vectors of diseases, a list of disease-gene associations, a matrix of genes' graphlet signature in a PPI network and a weight vector of 73 orbits in graphlet theory, this function will calculate disease similarity by method Sun_function

Usage

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Sun_topology(D1, D2, d2g, graphlet_sig_mat, weight)

Arguments

D1

a vector consists disease ids

D2

another vector consists disease ids

d2g

a list of disease-gene associations

graphlet_sig_mat

matrix of graphlet signature of nodes in a ppi network calculated by orca, see examples below.

weight

a vector which elements are weight factors to each orbit in graphlet theory

Value

a disease disease similarity matrix

Author(s)

Peng Ni, Min Li

References

Sun K, Goncalves JP, Larminie C. Predicting disease associations via biological network analysis[J]. BMC bioinformatics, 2014, 15(1): 304.

Examples

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dSimer documentation built on Nov. 17, 2017, 12:51 p.m.