deSet-class: The differential expression class (deSet)

Description Slots Methods Note Author(s)

Description

The deSet class extends the ExpressionSet class. While the ExpressionSet class contains information about the experiment, the deSet class contains both experimental information and additional information relevant for differential expression analysis, explained below in Slots.

Slots

null.model

formula: contains the adjustment variables in the experiment. The null model is used for comparison when fitting the full model.

full.model

formula: contains the adjustment variables and the biological variables of interest.

null.matrix

matrix: the null model as a matrix.

full.matrix

matrix: the full model as a matrix.

individual

factor: contains information on which sample is from which individual in the experiment.

qvalueObj

S3 object: containing qvalue object. See qvalue for additional details.

Methods

as(ExpressionSet, "deSet")

Coerce objects of ExpressionSet to deSet.

lrt(deSet, ...)

Performs a generalized likelihood ratio test using the full and null models.

odp(deSet, ...)

Performs the optimal discovery procedure, which is a new approach for optimally performing many hypothesis tests in a high-dimensional study.

kl_clust(deSet, ...)

An implementation of mODP that assigns genes to modules based off of the Kullback-Leibler distance.

fit_models(deSet, ...)

Fits a linear model to each gene by method of least squares.

apply_qvalue(deSet, ...)

Applies qvalue function.

apply_snm(deSet, ...)

Applies surpervised normalization of microarrays (snm) on gene expression data.

apply_sva(deSet, ...)

Applies surrogate variable analysis (sva).

fullMatrix(deSet)

Access and set full matrix.

nullMatrix(deSet)

Access and set null matrix.

fullModel(deSet)

Access and set full model.

nullModel(deSet)

Access and set null model.

individual(deSet)

Access and set individual slot.

qvalueObj(deSet)

Access qvalue object. See qvalue.

validObject(deSet)

Check validity of deSet object.

Note

See ExpressionSet for additional slot information.

Author(s)

John Storey, Jeffrey Leek, Andrew Bass


edge documentation built on Nov. 8, 2020, 6:48 p.m.