khan: Microarray gene expression dataset from Khan et al., 2001....

Description Usage Format Details Source References Examples

Description

Khan contains gene expression profiles of four types of small round blue cell tumours of childhood (SRBCT) published by Khan et al. (2001). It also contains further gene annotation retrieved from SOURCE at http://source.stanford.edu/.

Usage

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Format

Khan is dataset containing the following:

Details

Khan et al., 2001 used cDNA microarrays containing 6567 clones of which 3789 were known genes and 2778 were ESTs to study the expression of genes in of four types of small round blue cell tumours of childhood (SRBCT). These were neuroblastoma (NB), rhabdomyosarcoma (RMS), Burkitt lymphoma, a subset of non-Hodgkin lymphoma (BL), and the Ewing family of tumours (EWS). Gene expression profiles from both tumour biopsy and cell line samples were obtained and are contained in this dataset. The dataset downloaded from the website contained the filtered dataset of 2308 gene expression profiles as described by Khan et al., 2001. This dataset is available from the http://bioinf.ucd.ie/people/aedin/R/.

In order to reduce the size of the MADE4 package, and produce small example datasets, the top 50 genes from the ends of 3 axes following bga were selected. This produced a reduced datasets of 306 genes.

Source

khan contains a filtered data of 2308 gene expression profiles as published and provided by Khan et al. (2001) on the supplementary web site to their publication http://research.nhgri.nih.gov/microarray/Supplement/.

References

Culhane AC, et al., 2002 Between-group analysis of microarray data. Bioinformatics. 18(12):1600-8.

Khan,J., Wei,J.S., Ringner,M., Saal,L.H., Ladanyi,M., Westermann,F., Berthold,F., Schwab,M., Antonescu,C.R., Peterson,C. et al. (2001) Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks. Nat. Med., 7, 673-679.

Examples

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made4 documentation built on May 2, 2018, 2:37 a.m.

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