scHOT: single-cell higher order testing

Single cell Higher Order Testing (scHOT) is an R package that facilitates testing changes in higher order structure of gene expression along either a developmental trajectory or across space. scHOT is general and modular in nature, can be run in multiple data contexts such as along a continuous trajectory, between discrete groups, and over spatial orientations; as well as accommodate any higher order measurement such as variability or correlation. scHOT meaningfully adds to first order effect testing, such as differential expression, and provides a framework for interrogating higher order interactions from single cell data.

Package details

AuthorShila Ghazanfar [aut, cre], Yingxin Lin [aut]
Bioconductor views GeneExpression RNASeq Sequencing SingleCell Software Transcriptomics
MaintainerShila Ghazanfar <>
Package repositoryView on Bioconductor
Installation Install the latest version of this package by entering the following in R:
if (!requireNamespace("BiocManager", quietly = TRUE))


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scHOT documentation built on Nov. 8, 2020, 5:06 p.m.