PCT: Procalcitonin as diagnostic marker for sepsis

PCTR Documentation

Procalcitonin as diagnostic marker for sepsis

Description

Procalcitonin is a promising marker for identification of bacterial infections. The accuracy and clinical value of procalcitonin for diagnosis of sepsis in critically ill patients was assessed in this meta-analysis.

Medline, Embase, ISI Web of Knowledge, the Cochrane Library, Scopus, BioMed Central, and Science Direct were searched, from inception to Feb 21, 2012, and reference lists of identified primary studies. We included articles written in English, German, or French that investigated procalcitonin for differentiation of septic patients–those with sepsis, severe sepsis, or septic shock–from those with a systemic inflammatory response syndrome of non-infectious origin. Studies of healthy people, patients without probable infection, and children younger than 28 days were excluded. Two independent investigators extracted patient and study characteristics; discrepancies were resolved by consensus.

This search returned 3487 reports, of which 30 fulfilled the inclusion criteria, accounting for 3244 patients.

Usage

data("PCT")

Format

A data frame consisting of 35 data sets (rows) and 10 attributes (columns)

Variable Names in order from left to right:

Study

Study


Year

Year


TP

True positive


FP

False positive


FN

False negative


TN

True negative


logitTPR

logit-true positive rate


logitTNR

logit-true negative rate


varlogitTPR

Variance of logit TPR


varlogitTNR

Variance of logit TPR


References

Wacker C, Prkno A, Brunkhorst FM, Schlattmann P. Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis. Lancet Infect Dis. 2013 May;13(5):426-35. doi: 10.1016/S1473-3099(12)70323-7

Examples

#Use the VEM-algorithm for a diagnostic meta-analysis based on a mixture 
#of bivariate  normal densities.
#Study specific fixed variances are based on logit transformed 
#sensitivity and specificity. 

data(PCT)
names(PCT)
   
m0 <- bivariate.VEM(obs1 = logitTPR, obs2 = logitTNR,
                    var1 = varlogitTPR, var2 = varlogitTNR,
                    type = "meta", data=PCT, startk=20)

CAMAN documentation built on Sept. 22, 2023, 5:12 p.m.

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