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DMR4glm_help <- function(X, y, clust.method, lam){
n <- nrow(X)
nn <- sapply(1:ncol(X), function(i) class(X[,i]))
names(nn) <- colnames(X)
nn[nn == "integer"] <- "numeric"
x.full <- stats::model.matrix(y~., data = data.frame(y=y, X, check.names = TRUE))
p <- ncol(x.full)
lmin <- lam*length(y)*2
lmax <- lmin*1000
RL <- exp(seq(log(lmax), log(lmin), length.out = 20))
m <- glmnet::glmnet(x.full, y, lambda = RL, alpha = 0, family = "binomial") #SzN per explanation of PP, this is regularized with ridge penalty (alpha=0) to help with computations of singular cases, but not to sparsify the betas as lasso penalty could
be <- c(m$a0[20], m$beta[-1,20])
faki <- which(nn == "factor")
n.factors <- length(faki)
if (n.factors > 0){
n.levels <- sapply(1:n.factors, function(i) length(levels(X[,faki[i]])))
p.fac <- sum(n.levels - 1)
} else{
p.fac <- 0
}
cont <- which(nn == "numeric")
n.cont <- length(cont)
namCont <- names(nn)[cont]
zb <- exp(x.full%*%be)
pix <- zb/(zb + 1)
w <- as.numeric(pix*(1-pix))
Kan <- t(x.full*w)%*%x.full
#W <- diag(as.numeric(pix*(1-pix)))
# Kan <- t(x.full)%*%W%*%x.full
S <- solve(Kan + diag(rep(2*lam, p)))
Var <- S%*%Kan%*%S
if (n.factors > 0){
Wmats <- lapply(1:n.factors, function(i) {
i1 <- ifelse(i == 1, 2, sum(n.levels[1:(i - 1)] - 1) + 2)
i2 <- sum(n.levels[1:i] - 1) + 1
out <- w_stats(be[i1:i2], Var[i1:i2, i1:i2], ind1 = i1, ind2 = i2)
out[ out<0 ] <- lam #this fix is for DMRnet, it replaces negative values with a very small positive number. The reason negative values are out there is numerical instability when Kan is very close to 0 and Var is not symmetric, then w_stats produces negative numbers
rownames(out) <- colnames(out) <- levels(X[,faki[i]])
return(out)
})
#cutting dendrograms
models <- lapply(Wmats, function(x) stats::hclust(stats::as.dist(t(x)), method = clust.method, members = NULL))
heig <- lapply(1:n.factors, function(x){
out <- models[[x]]$he
names(out)<- rep(x, length(out))
out
})
heig <- unlist(heig)
} else {
heig <- c()
models <- list()
}
heig <- c(0,heig)
names(heig)[1] = "full"
if ((p.fac + 1) < p){
heig.add <- be[(p.fac + 2):p]^2/Var[cbind((p.fac + 2):p,(p.fac + 2):p)]
names(heig.add) <- colnames(x.full)[(p.fac + 2):p]
heig <- c(heig, heig.add)
}
heig <- sort(heig)
len <- length(heig)
#fitting models on the path
Z1 <- Z2 <- c()
sp <- list()
form <- c()
nl <- 0
Z1 <- X[, faki, drop = FALSE]
if (n.factors > 0){
for (i in 1:n.factors){
sp[[i]] <- 1:n.levels[i]
sp[[i]][sp[[i]] != 1] <- sp[[i]][sp[[i]] != 1] + nl
nl <- nl + length(unique(sp[[i]])) - 1
}
}
Z2 <- X[,namCont, drop = FALSE]
Z <- cbind(Z1,Z2)
dane <- data.frame(y=y, Z, check.names = T)
ZZ <- stats::model.matrix(y~., data = dane)
m <- glmnet::glmnet(ZZ, y, lambda = RL, alpha = 0, family = "binomial") #SzN per explanation of PP, this is regularized with ridge penalty (alpha=0) to help with computations of singular cases, but not to sparsify the betas as lasso penalty could
b <- c(m$a0[20], m$beta[-1,20])
names(b) <- colnames(ZZ)
zb = exp(ZZ%*%b) #in original AP's code this line was zb = exp(ZZ%*%be), but that was a copy-paste bug from somewhere else and got fixed. The bug got identified thanks to a symmetric bug in GLAMER's cluster_4glm_help() function line 91, which got corrected in commit 175cffa
pix = zb/(zb + 1)
loglik = sum(log(pix)[y == 1]) + sum(log(1-pix)[y == 0]) - lam*sum(m$beta@x^2)
form <- namCont
if (len > 2){
for (i in 2:(len - 1)){
kt <- names(heig)[i]
if(length(intersect(kt, namCont)) > 0){
form <- form[-which(form == kt)]
Z2 <- Z2[, form, drop = FALSE]
} else {
kt <- as.numeric(kt)
spold <- sp[[kt]]
sp[[kt]] <- stats::cutree(models[[kt]], h = heig[i])
if(length(sp[[kt]][sp[[kt]] != 1]) > 0){
sp[[kt]][sp[[kt]] != 1] <- sp[[kt]][sp[[kt]] != 1] + min(spold[spold != 1]) - min(sp[[kt]][sp[[kt]] != 1])
}
Z1[,kt] <- X[, faki[kt]]
levels(Z1[,kt]) <- sp[[kt]]
Z1[,kt] <- factor(Z1[,kt])
if (kt < length(sp)) for( x in (kt+1):length(sp)){ if (length(sp[[x]][sp[[x]]!=1]) > 0 ) sp[[x]][sp[[x]]!= 1] = sp[[x]][sp[[x]]!=1] - 1}
nl <- nl - 1
}
Z <- cbind(Z1[,which(apply(Z1, 2, function(x) length(unique(x))) != 1)], Z2)
dane <- data.frame(y = y, Z, check.names = T)
ZZ <- stats::model.matrix(y~., data = dane)
m <- glmnet::glmnet(ZZ, y, lambda = RL, alpha = 0, family = "binomial")
be <- c(m$a0[20], m$beta[-1,20])
zb = exp(ZZ%*%be)
pix = zb/(zb + 1)
loglik = c(loglik, sum(log(pix)[y == 1]) + sum(log(1-pix)[y == 0]) - lam*sum(m$beta[-1,20]^2))
be[1] <- 0
bb <- c()
if(n.factors > 0){
bb <- unlist(sapply(1:length(sp), function(j) sp[[j]][-1]))
}
bb2 <- rep(1, n.cont)
names(bb2) <- namCont
if(length(form) > 0){
bb2[form] <- (nl + 2):(nl + 1 + length(form))
}
bb <- c(bb, bb2)
b=cbind(b, c(m$a0[20], be[bb]))
}
}
m <- stats::glm.fit(as.matrix(rep(1, length(y))), y, family = stats::binomial())
min_value <- min(c(abs(m$coef[!is.na(m$coef)]), abs(b[!is.na(b) & (b!=0)])))
b[is.na(b)] <- min_value / 1000.0
m$coef[is.na(m$coef)] <- min_value / 1000.0 #setting a very small (close to 0) value for the variables exceeding design matrix rank
#consult the comment in part2beta_help() for longer explanation
b = cbind(b, c(m$coef, rep(0, length(heig) - 1)))
zb = exp(m$coef*rep(1, length(y)))
pix = zb/(zb + 1)
loglik = c(loglik, sum(log(pix)[y == 1]) + sum(log(1-pix)[y == 0]))
return(list(beta = b, loglik = loglik))
}
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