Calculate normal tissue complication probability (NTCP) from Lyman's probit model, Niemierko's logit model, or the Poisson model. May be based on EQD2.
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18  getNTCP(x, NTCPtd50=NULL, NTCPm=NULL, NTCPn=NULL, NTCPgamma50=NULL,
EUDa=NULL, EUDfn=NULL, EUDab=NULL,
NTCPtype=c("probit", "logit", "poisson"), ...)
## S3 method for class 'DVHs'
getNTCP(x, NTCPtd50=NULL, NTCPm=NULL, NTCPn=NULL, NTCPgamma50=NULL,
EUDa=NULL, EUDfn=NULL, EUDab=NULL,
NTCPtype=c("probit", "logit", "poisson"), ...)
## S3 method for class 'DVHLst'
getNTCP(x, NTCPtd50=NULL, NTCPm=NULL, NTCPn=NULL, NTCPgamma50=NULL,
EUDa=NULL, EUDfn=NULL, EUDab=NULL,
NTCPtype=c("probit", "logit", "poisson"), ...)
## S3 method for class 'DVHLstLst'
getNTCP(x, NTCPtd50=NULL, NTCPm=NULL, NTCPn=NULL, NTCPgamma50=NULL,
EUDa=NULL, EUDfn=NULL, EUDab=NULL,
NTCPtype=c("probit", "logit", "poisson"), ...)

x 
One cumulative DVH (object of class 
NTCPtd50 
Tolerance dose with 50% complication probability. 
NTCPm 
Probit/logit Parameter m. Equal to 1 / (NTCPgamma50*sqrt(2*pi)). 
NTCPn 
Parameter n. Equal to 1/a with exponential gEUD paramter a. 
NTCPgamma50 
Poisson parameter gamma50. Equal to 1 / (NTCPm*sqrt(2*pi)) 
EUDa 
If gEUD should be based on EQD2: Exponential parameter a. 
EUDfn 
If gEUD should be based on EQD2: Number of fractions. 
EUDab 
If gEUD should be based on EQD2: alpha/beta ratio for the relevant tissue. 
NTCPtype 

... 
Ignored. Used to catch additional arguments passed from 
For DVH reduction, gEUD is used. This is equivalent to the KutcherBurman DVH reduction scheme. The probit model is given in equation (1), the logit model in eqation (2), and the Poisson model in equation (3) in Kaellman (1992), with gEUD plugged in for D.
A data frame with variables NTCP
, patID
, and structure
.
Kaellman, P., Agren, A., & Brahme, A. (1992). Tumor and normal tissue responses to fractionated nonuniform dose delivery. International Journal of Radiation Biology, 62(2), 249262.
Kutcher, G. J., Burman, C., Brewster L., Goitein, M., & Mohan, R. (1991). Histogram reduction method for calculating complication probabilities for threedimensional treatment planning evaluations. International Journal of Radiation Oncology Biology Physics, 21(1), 137146.
Lyman, J. T. (1985). Complication probability as assessed from dose volume histograms. Radiation Research, 104(2), S1319.
Niemierko, A. (1999). A generalized concept of equivalent uniform dose. Medical Physics, 26(6), 1100.
Rancati et al. (2004). Fitting late rectal bleeding data using different NTCP models: results from an Italian multicentric study (AIROPROS0101). Radiotherapy Oncology, 73, 2132.
getTCP
,
getEUD
,
getMetric
1 2 
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