EWOC2-package: Escalation with Overdose Control using 2 Drug Combinations

Description Author(s) References

Description

Implements escalation with overdose control (EWOC) trial designs using two drug combinations described by Tighiouart, Li and Rogatko (2017) <doi:10.1002/sim.6961>. It calculates the recommended dose for next cohorts and perform simulations to obtain operating characteristics.

Author(s)

Quanlin Li and Mourad Tighiouart

Maintainer: Quanlin Li <choplum@gmail.com>

References

Tighiouart M, Li Q and Rogatko A. A Bayesian adaptive design for estimating the maximuym tolerated dose curve using drug combinations in cancer phase I clinical trials. Statistics in Medicine. 2017, 36: 280-290.


EWOC2 documentation built on May 2, 2019, 2:46 a.m.