mtdcurve: Generating MTD curve based on logistic model for two drugs

In EWOC2: Escalation with Overdose Control using 2 Drug Combinations

Description

Generating MTD curve based on logistic model for two drugs

Usage

mtdcurve(rho00, rho01, rho10, eta, theta)

Arguments

rho00	a numeric value indicating the true value of the parameter rho00, the probability of DLT when the levels of drugs A and B are both 0
rho01	a numeric value indicating the true value of the parameter rho01, the probability of DLT when the levels of drugs A and B are 0 and 1, respectively
rho10	a numeric value indicating the true value of the parameter rho10, the probability of DLT when the levels of drugs A and B are 1 and 0, respectively
eta	a numeric value indicating the true value of the eta, the interaction parameter
theta	a numerical value defining the proportion of expected patients to experience a medically unacceptable, dose-limiting toxicity (DLT) if administered the MTD

Value

none

Examples

mtdcurve(rho00=0.01, rho01=0.2, rho10=0.9, eta=20, theta=0.2)

EWOC2 documentation built on May 2, 2019, 2:46 a.m.