pdlt: Generating probability of DLT based on the EWOC2 model

In EWOC2: Escalation with Overdose Control using 2 Drug Combinations

Description

Generating probabiity of DLT based on the EWOC 2 drugs combination model

Usage

pdlt(rho00, rho01, rho10, eta, theta, x, y)

Arguments

rho00	a numeric value indicating the true value of the parameter rho00, the probability of DLT when the levels of drugs A and B are both 0
rho01	a numeric value indicating the true value of the parameter rho01, the probability of DLT when the levels of drugs A and B are 0 and 1, respectively
rho10	a numeric value indicating the true value of the parameter rho10, the probability of DLT when the levels of drugs A and B are 1 and 0, respectively
eta	a numeric value indicating the true value of the eta, the interaction parameter
theta	a numerical value defining the proportion of expected patients to experience a medically unacceptable, dose-limiting toxicity (DLT) if administered the MTD
x	a numeric value of dose level for drug A
y	a numeric value of dose level for drug B

Value

a numeric value indicating the probability of DLT with doses from input based on the logistic model

Examples

pdlt(rho00=0.01, rho01=0.2, rho10=0.9, eta=20, theta=0.2, x=0.2, y=0.3)

EWOC2 documentation built on May 2, 2019, 2:46 a.m.