modules.icm: Modules for Stochastic Individual Contact Models

In EpiModel: Mathematical Modeling of Infectious Disease Dynamics

Modules for Stochastic Individual Contact Models

Description

Stochastic individual contact models of infectious disease simulate epidemics in which contacts between individuals are instantaneous events in discrete time. They are intended to be the stochastic microsimulation analogs to deterministic compartmental models.

The icm function handles both the simulation tasks. Within this function are a series of modules that initialize the simulation and then simulate new infections, recoveries, and vital dynamics at each time step. A module also handles the basic bookkeeping calculations for disease prevalence.

Writing original ICMs will require modifying the existing modules or adding new modules to the workflow in icm. The existing modules may be used as a template for replacement or new modules.

This help page presents a brief overview of the module functions in the order in which they are used within icm, in order to help guide users in writing their own module functions. These module functions are not shown on the help index since they are not called directly by the end-user. To understand these functions in more detail, review the separate help pages listed below.

Initialization Module

This function sets up agent attributes, like disease status, on the network at the starting time step of disease simulation, t_1. For multiple-simulation function calls, these are reset at the beginning of each simulation.

• initialize.icm: sets which agents are initially infected, through the initial conditions passed in init.icm.

Disease Status Modification Modules

The main disease simulation occurs at each time step given the current state of the population at that step. Infection of agents is simulated as a function of disease parameters and population composition. Recovery of agents is likewise simulated with respect to infected nodes. These functions also analyze the flows for summary measures such as disease incidence.

• infection.icm: randomly draws an edgelist given the parameters, subsets the list for discordant pairs, and simulates transmission on those discordant pairs through a series of draws from a binomial distribution.

• recovery.icm: simulates recovery from infection either to a lifelong immune state (for SIR models) or back to the susceptible state (for SIS models), as a function of the recovery rate specified in the rec.rate parameter. The recovery rate may vary for two-group models.

Demographic Modules

Vital dynamics such as arrival and departure processes are simulated at each time step to update entries into and exits from the population. These are used in open-population ICMs.

• departures.icm: randomly simulates departures or exits for agents given the departure rate specified in the disease-state and group-specific departure parameters in param.icm. This involves deactivating agents from the population, but their historical data is preserved in the simulation.

• arrivals.icm: randomly simulates new arrivals into the population given the current population size and the arrival rate parameters. This involves adding new agents into the population.

Bookkeeping Module

Simulations require bookkeeping at each time step to calculate the summary epidemiological statistics used in the model output analysis.

• prevalence.icm: calculates the number in each disease state (susceptible, infected, recovered) at each time step for those active agents in the population.

EpiModel documentation built on Oct. 12, 2024, 1:06 a.m.