binom_one_alpha: Single arm, exact p-value calculator for single or...
In EurosarcBayes: Bayesian Single Arm Sample Size Calculation Software

Description Usage Arguments See Also Examples

P-value (alpha) for single arm binomial clinical trials. This is done exactly accounting for all interim analysis prior to stopping the trial.

1	binom_one_alpha(result.success, result.n, p0, failure, success, n)

`result.success`	total successes at the end of the trial
`result.n`	total patients at the end of the trial
`p0`	Probability of success under H0
`failure`	A vector of the number of failures required to stop for futility, if not able to stop NA or a character string should be provided
`success`	A vector of the number of successes required to stop for efficacy, if not able to stop NA or a character string should be provided
`n`	A vector of the total number of patients to recruit up to each stage of the trial

binom_one_power, binom_one_assurance

# Simon's two stage design
failure=c(0,3)
success=c(NA,4)
n=c(7,18)
p0=0.1

result.success=4
result.n=18

# without accounting for interim analysis when calculating 
# the p-value
1-pbinom(result.success-1,result.n,p0)
# account for interim analysis
binom_one_alpha(result.success,result.n,p0,failure,success,n)