Description Usage Arguments Value References Examples
View source: R/freq_binom_one_landemets_v1.0.R
Sample size calculation for single arm, multistage trials using the alpha spending approach to reduce type I and type II error rates. This implimentation uses the O'Brien-Fleming alpha spending function for this purpose.
1 2 | freq_binom_one_landemets(reviews, p0, p1, r=c(p0,p1),
alpha=0.1, beta=0.1, prior.a=0, prior.b=0)
|
reviews |
A vector of the number of patients to perform interim analysis at |
p0 |
Probability of success under the H0 |
p1 |
Probability of success under the H1 |
r |
A vector of probabilities used to perform simulations from |
alpha |
The largest allowed value for the frequentist type one error |
beta |
The smallest allowed value for the frequentist type two error |
prior.a, prior.b |
Prior parameters for the beta prior |
Returns an object of class trialDesign_binom_one
DeMets, D. L. and G. Lan (1995). The alpha spending function approach to interim data analyses. Cancer Treat Res 75: 1-27.
O'Brien, P. C. and T. R. Fleming (1979). A Multiple Testing Procedure for Clinical Trials. Biometrics 35(3): 549-556.
1 2 3 4 5 6 7 | reviews=c(11,22,33,44)
p0=0.2
p1=0.35
r=c(0.2,0.35)
alpha=0.1
beta=0.2
freq_binom_one_landemets(reviews,p0,p1,r,alpha,beta)
|
Loading required package: shiny
Loading required package: VGAM
Loading required package: stats4
Loading required package: splines
Loading required package: data.table
Loading required package: plyr
Loading required package: clinfun
n futility efficacy
1 11 NA 7
2 22 2 9
3 33 7 10
4 44 11 12
Stopping rules R=0.2 R=0.35
1 Stop early - Futility 66.70 6.67
2 Stop early - Efficacy 10.82 77.14
3 Continue to final analysis - Efficacy 5.65 11.48
4 Continue to final analysis - Futility 16.83 4.71
5 Inconclusive 0.00 0.00
6 Expected number of patients recruited 33.52 30.25
Trial design and properties for single arm, single endpoint trial designs
reviews success failure
11 7 NA
22 9 2
33 10 7
44 12 11
p0 : 0.2
p1 : 0.35
Alpha : 16.47
Power : 88.62
Exp(p0): 33.52
Exp(p1): 30.25
Eta : 0.179
Zeta : 0.026
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