Identify Cancer Dysfunctional Sub-pathway by integrating gene expression, DNA methylation and copy number variation, and pathway topological information. 1)We firstly calculate the gene risk scores by integrating three kinds of data: DNA methylation, copy number variation, and gene expression. 2)Secondly, we perform a greedy search algorithm to identify the key dysfunctional sub-pathways within the pathways for which the discriminative scores were locally maximal. 3)Finally, the permutation test was used to calculate statistical significance level for these key dysfunctional sub-pathways.
|Author||Junwei Han [cre], Baotong Zheng [aut], Siyao Liu [ctb]|
|Maintainer||Junwei Han <email@example.com>|
|License||GPL (>= 2)|
|Package repository||View on CRAN|
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