envData: The variables in the environment include an example...

Description Format Details Author(s)

Description

Identify Cancer Dysfunctional Subpathway by integrating gene expression, DNA methylation and copy number variation, and pathway topological information. 1)We firstly calculate the gene risk scores by integrating three kinds of data: DNA methylation, copy number variation, and gene expression. 2)Secondly, we perform a greedy search algorithm to identify the key dysfunctional subpathways within the pathways for which the discriminative scores were locally maximal. 3)Finally, the permutation test was used to calculate statistical significance level for these key dysfunctional subpathways.

Format

An environment variable

Details

The environment variable includes the variable exp_data, meth_data,cnv_data,amp_gene,del_gene,zzz,exp.p,meth.p,cnv.p,label1,label2,subpathdata,opt_subpathways

Author(s)

Junwei Hanhanjunwei1981@163.com,Baotong Zhengbtzheng1116@163.com,Siyao Liu liusiyao29@163.com


ICDS documentation built on July 15, 2021, 5:06 p.m.