Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) is the premier technology for profiling genome-wide localization of chromatin-binding proteins, including transcription factors and histones with various modifications. This package provides a robust method for normalizing ChIP-seq signals across individual samples or groups of samples. It also designs a self-contained system of statistical models for calling differential ChIP-seq signals between two or more biological conditions as well as for calling hypervariable ChIP-seq signals across samples. Refer to Tu et al. (2021) <doi:10.1101/gr.262675.120> and Chen et al. (2021) <doi:10.1101/2021.07.27.453915> for associated statistical details.
|Author||Shiqi Tu [aut, cre] (<https://orcid.org/0000-0003-3534-5714>)|
|Maintainer||Shiqi Tu <email@example.com>|
|Package repository||View on CRAN|
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