pafway: Find pairwise-associations between annotations in a network...

In PAFway: Pairwise Association of Functional Annotations

Description

Find pairwise-associations between annotations in a network without edge weights.

Usage

pafway(GO, edges, GOtypes, exact = TRUE, adjustByEdgeCount = FALSE)

Arguments

GO	A vector of Strings, equal to the length of all the nodes. The names of the vector should be the names of the nodes. The values should either be the functional annotations, or a concatenation of the functional annotations, separated by a "_" symbol.
edges	A matrix of Strings, with at least two columns. Each row will represent an edge, linking the node in the first column to the node in the second column. Please make sure the node names are the same as those in "GO"
GOtypes	This is a vector that contains the functional annotations or GO terms that are of interest
exact	A boolean. If it is true, it will look for an exact match between the term in GOtypes and the vector GO. Otherwise, it will look for substrings.
adjustByEdgeCount	A boolean. If true, then the probability of observing a functional annotation will be calculated in terms of the number of nodes, but if it is false, it is calculated in terms of the number of edges that contain that node.

Value

A matrix that has the same number of rows and columns as length(GOtypes). This will contain p-values.

Examples

nodes=paste("node", c(1:10))
set.seed(123)
randomGO=c("A", "B", "C")[sample(c(1:3), 10, replace=TRUE)]
names(randomGO)=nodes
edgesRandom=sapply(c(1:100), function(i){
   nodes[sample(10, 2)]
})
pafway(randomGO, t(edgesRandom), unique(randomGO))

PAFway documentation built on Feb. 6, 2020, 5:13 p.m.