PKNews: Shows changes and news
In PK: Basic Non-Compartmental Pharmacokinetics

Description Usage Details Value Author(s) Examples

Functions showing changes since previous versions.

PKNews()

Displays the changes and news given in the NEWS file of the package.

Screen output.

Thomas Jaki

PKNews()

 **********   PK Version 1.3-3********** 

Type PKNews() to see new features/changes/bug fixes.

---------------------PK NEWS----------------------------------------------

PK is an R package for inference for PK parameters in complete and 
incomplete data designs based on non-compartmental methods. If you are 
using the package, please cite it as 

Jaki T and Wolfsegger MJ (2011) Estimation of pharmacokinetic parameters 
with the R package PK. Pharmaceutical Statistics. Vol 10(No 3), 294-288. 
DOI: 10.1002/pst.449"

Question or suggestions about the package can be send to

   jaki.thomas@gmail.com
or
   martin_wolfsegger@baxter.com

--------------------CHANGE LOG--------------------------------------------
Version 1.3-3

  o Removal of depreciated function call

--------------------------------------------------------------------------
Version 1.3-2

  o A bug during start-up is corrected

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Version 1.3-1

  o depreciated functions as.real replaced by as.double

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Version 1.3-0

  o Flexible batch designs (Jaki & Wolfsegger, Statistics in Medicine 2012)
    implemented. These designs allow the same timepoints to be used in 
    different batches. 
    Functions updated:  auc.batch
    Help files updated: auc.batch, eqv.batch

  o Methods to compute PK parameters such as Clearance in flexible
    batch designs have been added in functions nca and nca.batch

  o Help for nca updated

  o Help for eqv.ssd, eqv.batch and eqv.complete has been merged with eqv

--------------------------------------------------------------------------
Version 1.2-5

  o Code in biexp and lee updated

  o Several examples in help files biexp and lee added 

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Version 1.2-4

  o The help file for the function nca has been corrected

  o Citation information updated

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Version 1.2-3

  o A bug in an internal function to handle the data argument in batch 
    designs fixed

  o Citation information updated

  o A bug in the nca.complete function fixed

  o A bug in the summary function fixed

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Version 1.2-2

  o A repeated dose toxicity dataset included

  o Help on nca function expanded

  o A bug in the print function fixed

  o auc.complete updated to handle individual AUCs

  o Additional example in help for auc.complete included

  o Function nca.complete included

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Version 1.2-1

  o Default option for method lee changed to ols

  o Functionality to create plots by group included

  o Some formating changes in the print/summary functions

  o Bug in print.PKtest fixed

  o Bug in test fixed

--------------------------------------------------------------------------
Version 1.2-0

  o Multiple datasets included

  o Bug in auc.batch fixed

  o Functions can now be called using data in FDA SEND format - http://www.cdisc.org/send

  o Functions est, ci and test have been included to obtain point estimates, confidence intervals and hypothesis tests

  o Functions auc, eqv, nca have been aligned

  o Methods to test for bioequivalence in batch designs for independent and dependent aucs have been added in functions eqv and eqv.batch

  o Methods to compute PK parameters such as MRT and Clearance in serial sampling designs have been added in functions nca and nca.ssd

  o Multiple references added and updated