Rats: Plasma levels in female rats following a single oral dose

In PK: Basic Non-Compartmental Pharmacokinetics

Plasma levels in female rats following a single oral dose

Description

The Rats data frame has 126 rows and 4 columns.

Format

This data frame contains the following columns:

id

a numeric vector identifying the animal whose plasma level is measured.

conc

a numeric vector giving the measured plasma level (microgram/mL).

time

a numeric vector giving the time since administration (hours).

dose

a numeric vector indicating the dose administred (mg/kg).

Details

Holder et al. (1999), Table 4 describes data on the plasma levels measured at 6 time points over 24 hours for 9 female rats. The same experiment was repeated with different oral dosages.

Source

Holder D. J., Hsuan F., Dixit R. and Soper K. (1999). A method for estimating and testing area under the curve in serial sacrifice, batch, and complete data designs. Journal of Biopharmaceutical Statistics, 9(3):451-464.

PK documentation built on Sept. 12, 2023, 9:06 a.m.