Endometrial: Exogenous Oestrogens and Endometrial Cancer.

In R4HCR: R for Health Care Research

Exogenous Oestrogens and Endometrial Cancer.

Description

This is a matched case control study investigated the effect of exogenous oestrogens on the risk of endometrial cancer.

Usage

Endometrial

Format

A data frame with 126 observations on the following 8 variables.

set

Matched pair indicator (1 - 63).

case

Indicator for case/control status (0 = control, 1 = case).

gallbladder

History of gallbladder disease (0 = No, 1 = Yes).

hypertension

History of hypertension (0 = No, 1 = Yes).

obesity

Obesity (0 = No, 1 = Yes).

estrogen

Any use of estrogen (0 = No, 1 = Yes).

age

Age of the women.

dose

Conjugated estrogen dose (1 = none, 2 = 0.1-0.299 mg, 3 = 0.3-0.625 mg and 4 = 0.626+ mg).

Details

Investigators matched 63 cases of endometrial cancer with four control women who were alive and living in the community at the time the case was diagnosed, who were born within one year of the case, who had the same marital status, and who had entered the community at approximately the same time. This data set includes all 63 cases and the first matched control, as per the results in Table 7.3 (page 255) of Breslow and Day (1980).

Source

Breslow, N.E., Day, N.E. and Heseltine, E., 1980. Statistical Methods in Cancer Research.

References

Mack, T.M., Pike, M.C., Henderson, B.E., Pfeffer, R.I., Gerkins, V.R., Arthur, M. and Brown, S.E., 1976. Estrogens and endometrial cancer in a retirement community. New England Journal of Medicine, 294(23), pp.1262-1267.

Examples

require(survival)

data(Endometrial, package = "R4HCR")

# Conditional logistic regression.
mod2 <- clogit(case ~ estrogen + strata(set), data = Endometrial)

summary(mod2)

R4HCR documentation built on Sept. 30, 2024, 9:46 a.m.