Remission: Effect of 6-mercaptopurine (6-MP) on the Duration of...
In R4HCR: R for Health Care Research

Remission

R Documentation

Effect of 6-mercaptopurine (6-MP) on the Duration of Remission in Acute Leukemia.

Description

Duration of remission for acute leukemia patients on active treatment or placebo.

Usage

Remission

Format

A data frame with 42 observations on the following 5 variables.

sex: Sex of the patient (0 = male, 1 = female).
wbc: log white-blood cell count (WBC).
time: Time to event, where the event is either relapse or loss to follow up.
event: Indicator of event type, either Relapse or Censored.
grp: Treatment group (6-MP = allocated to active treament, or Placebo).

Details

In this study, patients in remission were randomly assigned to maintenance therapy with 6-MP, an active antileukemic compound 6-MP, or a placebo. White blood cell count was also recorded as this was considered a prognostic indicator of survival for leukemia patients, with the higher values being associated with a worse prognosis.

Source

Kleinbaum, D.G. and Klein, M., 1996. Survival Analysis: A Self-Learning Text. Springer.

References

Acute Leukemia Group B, Freireich, E.J., Gehan, E., Frei III, E.M.I.L., Schroeder, L.R., Wolman, I.J., Anbari, R., Burgert, E.O., Mills, S.D., Pinkel, D. and Selawry, O.S., 1963. The effect of 6-mercaptopurine on the duration of steroid-induced remissions in acute leukemia: A model for evaluation of other potentially useful therapy. Blood, 21(6), pp.699-716.

Examples

data(Remission, package = "R4HCR")

# Number of events/censored by group
aggregate(event ~ grp,
data = Remission,
FUN = table)

# median survival times, ignoring the censoring.
aggregate(time ~ grp,
data = Remission,
FUN = median)

R4HCR documentation built on Sept. 30, 2024, 9:46 a.m.