NPguided: NP Guided Monitoring of Heart Failure.

In R4HCR: R for Health Care Research

NP Guided Monitoring of Heart Failure.

Description

Data from a meta-analysis of natriuretic peptide-guided (NP-guided) treatment for heart failure.

Usage

NPguided

Format

A data frame with 18 observations on the following 7 variables.

studyid

Name and year of study.

year

Year of publication.

eventsnp

Number of events (all-cause mortality) in NP-guided monitoring group.

totalnp

Total number of participants in NP-guided monitoring group.

eventscntrl

Number of events (all-cause mortality) with treatment guided by clinical assessment alone.

totalcntrl

Total number of participants with treatment guided by clinical assessment alone.

comparator

Indicator for type of comparator arm in study (0 = usual care, 1 = clinical assessment).

Details

Natriuretic peptides (NP) are released by the myocardium in response to pressure or fluid overload and are raised in patients with heart failure (HF). NP is a collective term for N-terminal pro-B-type natriuretic peptide (NT-proBNP) and B-type natriuretic peptide (BNP). Studies compared NP-guided treatment to treatment guided by clinical assessment alone. These data are from a study that aimed to determine whether NP-guided treatment of patients with HF reduces all-cause mortality, amongst other outcomes.

References

McLellan J, Bankhead CR, Oke JL, Hobbs FDR, Taylor CJ, Perera R. Natriuretic peptide-guided treatment for heart failure: a systematic review and meta-analysis. BMJ Evid Based Med. 2020 Feb;25(1):33-37. \Sexpr[results=rd]{tools:::Rd_expr_doi("doi: 10.1136/bmjebm-2019-111208")}. Epub 2019 Jul 20. PMID: 31326896; PMCID: PMC7029248.

Examples

require(meta)

data(NPguided, package = "R4HCR")

metabin(
  sm = "RR",
  method = "MH",
  event.e = eventsnp,
  n.e = totalnp,
  event.c = eventscntrl,
  n.c = totalcntrl,
  studlab = studyid,
  data  = NPguided)

R4HCR documentation built on Sept. 30, 2024, 9:46 a.m.