getDrugSpw: SubtypeDrug internal function

In SubtypeDrug: Prioritization of Candidate Cancer Subtype Specific Drugs

Description

According to the parameters set by the user, the up-regulatory and down-regulatory subpathway data of drug is obtained.

Usage

getDrugSpw(
  drug_target_data,
  spw_matrix_rnames,
  drug.P.value.threshold,
  drug.min.sz,
  drug.max.sz
)

Arguments

drug_target_data	A list. A list stores a collection of drug up- and down-regulated subpathways.
spw_matrix_rnames	A vector. A vector consisting of row names of subpathway activity profile.
drug.P.value.threshold	A value. According to the threshold of the significant P value set by parameter 'drug.p.val.threshold', the drug up-regulation and down-regulatory subpathways were screened.
drug.min.sz	A numeric. The drug regulated subpathways intersects with the subpathways in the subpathway activity profile. Then drugs with less than 'drug.spw.min.sz' up- or down-regulated subpathways are removed.
drug.max.sz	A numeric. Similar to parameter 'drug.spw.min.sz', drugs with more than 'drug.spw.max.sz' up- or down-regulated subpathways are removed.

Details

getDrugSpw

Value

a list.

Author(s)

Xudong Han, Junwei Han, Chonghui Liu

Examples

require(GSVA)
Geneexp<-get("Geneexp")
UserGS<-get("UserGS")
UserDS<-get("UserDS")
spw_matrix<-gsva(Geneexp,UserGS,verbose=FALSE)
x<-getDrugSpw(UserDS,row.names(spw_matrix),0.05,1,100)

SubtypeDrug documentation built on May 17, 2021, 9:09 a.m.