colorectal: The Colorectal dataset with a binary surrogate.

In Surrogate: Evaluation of Surrogate Endpoints in Clinical Trials

The Colorectal dataset with a binary surrogate.

Description

This dataset combines the data that were collected in 26 double-blind randomized clinical trials in advanced colorectal cancer.

Usage

data("colorectal")

Format

A data frame with 3943 observations on the following 7 variables.

TRIAL

The ID number of a trial.

responder

Binary tumor response (the candidate surrogate), coded as 2=complete response (CR) or partial response (PR) and 1=stabled disease (SD) or progressive disease (PD).

SURVIND

Censoring indicator for survival time.

TREAT

The treatment indicator, coded as 0=active control and 1=experimental treatment.

CENTER

The center in which a patient was treated. In this dataset, there was only one center per trial, hence TRIAL=CENTER.

patientid

The ID number of a patient.

surv

Survival time (the true endpoint).

References

Alonso, A., Bigirumurame, T., Burzykowski, T., Buyse, M., Molenberghs, G., Muchene, L., ... & Van der Elst, W. (2016). Applied surrogate endpoint evaluation methods with SAS and R. CRC Press.

Examples

data(colorectal)
str(colorectal)
head(colorectal)

Surrogate documentation built on June 22, 2024, 9:16 a.m.