colorectal4: The Colorectal dataset with an ordinal surrogate.

In Surrogate: Evaluation of Surrogate Endpoints in Clinical Trials

The Colorectal dataset with an ordinal surrogate.

Description

This dataset combines the data that were collected in 19 double-blind randomized clinical trials in advanced colorectal cancer.

Usage

data("colorectal4")

Format

A data frame with 3192 observations on the following 7 variables.

trialend

The ID number of a trial.

treatn

The treatment indicator, coded as 0=active control and 1=experimental treatment.

trueind

Censoring indicator for survival time.

surrogend

Categorical ordered tumor response (the candidate surrogate), coded as 1=complete response (CR), 2=partial response (PR), 3=stabled disease (SD) and 4=progressive disease (PD).

patid

The ID number of a patient.

center

The center in which a patient was treated. In this dataset, there was only one center per trial, hence TRIAL=CENTER.

truend

Survival time (the true endpoint).

References

Alonso, A., Bigirumurame, T., Burzykowski, T., Buyse, M., Molenberghs, G., Muchene, L., ... & Van der Elst, W. (2016). Applied surrogate endpoint evaluation methods with SAS and R. CRC Press.

Examples

data(colorectal4)
str(colorectal4)
head(colorectal4)

Surrogate documentation built on June 22, 2024, 9:16 a.m.