Evaluation of Surrogate Endpoints in Clinical Trials

AA.MultS | Compute the multiple-surrogate adjusted association |

ARMD | Data of the Age-Related Macular Degeneration Study |

ARMD.MultS | Data of the Age-Related Macular Degeneration Study with... |

BifixedContCont | Fits a bivariate fixed-effects model to assess surrogacy in... |

BimixedContCont | Fits a bivariate mixed-effects model to assess surrogacy in... |

Bootstrap.MEP.BinBin | Bootstrap 95% CI around the maximum-entropy ICA and SPF... |

CausalDiagramBinBin | Draws a causal diagram depicting the median informational... |

CausalDiagramContCont | Draws a causal diagram depicting the median correlations... |

CIGTS | Data of the Collaborative Initial Glaucoma Treatment Study |

CIGTS_BinCont | Data of the Collaborative Initial Glaucoma Treatment Study... |

comb27.BinBin | Assesses the surrogate predictive value of each of the 27... |

ECT | Apply the Entropy Concentration Theorem |

Fano.BinBin | Evaluate the possibility of finding a good surrogate in the... |

FixedBinBinIT | Fits (univariate) fixed-effect models to assess surrogacy in... |

FixedBinContIT | Fits (univariate) fixed-effect models to assess surrogacy in... |

FixedContBinIT | Fits (univariate) fixed-effect models to assess surrogacy in... |

FixedContContIT | Fits (univariate) fixed-effect models to assess surrogacy in... |

FixedDiscrDiscrIT | Investigates surrogacy for binary or ordinal outcomes using... |

ICABinBin | Assess surrogacy in the causal-inference single-trial setting... |

ICABinBinCounterAssum | ICA (binary-binary setting) that is obtaied when the... |

ICA.BinBin.Grid.Full | Assess surrogacy in the causal-inference single-trial setting... |

ICA.BinBin.Grid.Sample | Assess surrogacy in the causal-inference single-trial setting... |

ICA.BinBin.Grid.Sample.Uncert | Assess surrogacy in the causal-inference single-trial setting... |

ICABinCont | Assess surrogacy in the causal-inference single-trial setting... |

ICAContCont | Assess surrogacy in the causal-inference single-trial setting... |

ICA.ContCont.Mult_alt | Assess surrogacy in the causal-inference single-trial setting... |

ICA.ContCont.MultS | Assess surrogacy in the causal-inference single-trial setting... |

ICA.Sample.ContCont | Assess surrogacy in the causal-inference single-trial setting... |

LongToWide | Reshapes a dataset from the 'long' format (i.e., multiple... |

MarginalProbs | Computes marginal probabilities for a dataset where the... |

MaxEntICABinBin | Use the maximum-entropy approach to compute ICA in the... |

MaxEntICAContCont | Use the maximum-entropy approach to compute ICA in the... |

MaxEntSPFBinBin | Use the maximum-entropy approach to compute SPF (surrogate... |

MICAContCont | Assess surrogacy in the causal-inference multiple-trial... |

MICA.Sample.ContCont | Assess surrogacy in the causal-inference multiple-trial... |

MinSurrContCont | Examine the plausibility of finding a good surrogate endpoint... |

MixedContContIT | Fits (univariate) mixed-effect models to assess surrogacy in... |

Ovarian | The Ovarian dataset |

plot.CausalInference | Plots the (Meta-Analytic) Individual Causal Association when... |

plot.comb27.BinBin | Plots the distribution of prediction error functions in... |

plot.Fano.BinBin | Plots the distribution of R^2_{HL} either as a density or as... |

Plot.FixedDiscrDiscrIT | Provides plots of trial-level surrogacy in the... |

plot.ICABinBin | Plots the (Meta-Analytic) Individual Causal Association and... |

plot.ICABinCont | Plots the (Meta-Analytic) Individual Causal Association and... |

plot.ICA.ContCont.Mult | Plots the Individual Causal Association in the setting where... |

plot.InformationTheoretic | Provides plots of trial- and individual-level surrogacy in... |

plot.InformationTheoreticBinCombn | Provides plots of trial- and individual-level surrogacy in... |

plot.InformationTheoreticSurvSurv | Provides plots of trial- and individual-level surrogacy in... |

plot.MaxEntContCont | Plots the sensitivity-based and maximum entropy based... |

plot.MaxEntICABinBin | Plots the sensitivity-based and maximum entropy based... |

plot.MaxEntSPFBinBin | Plots the sensitivity-based and maximum entropy based... |

plot.MetaAnalytic | Provides plots of trial- and individual-level surrogacy in... |

plot.MinSurrContCont | Graphically illustrates the theoretical plausibility of... |

plot.PPE.BinBin | Plots the distribution of either PPE, RPE or R^2_{H} either... |

Plot.PredTrialTContCont | Plots the expected treatment effect on the true endpoint in a... |

plot.SPPBinBin | Plots the surrogate predictive function (SPF) in the... |

plot.SPPBinCont | Plots the surrogate predictive function (SPF) in the... |

plot.TrialLevelIT | Provides a plots of trial-level surrogacy in the... |

plot.TrialLevelMA | Provides a plots of trial-level surrogacy in the... |

plot.TwoStageSurvSurv | Plots trial-level surrogacy in the meta-analytic framework... |

Pos.Def.Matrices | Generate 4 by 4 correlation matrices and flag the positive... |

PPE.BinBin | Evaluate a surrogate predictive value based on the minimum... |

Pred.TrialT.ContCont | Compute the expected treatment effect on the true endpoint in... |

Prentice | Evaluates surrogacy based on the Prentice criteria for... |

RandVec | Generate random vectors with a fixed sum |

Restrictions.BinBin | Examine restrictions in pi_{f} under different montonicity... |

Schizo | Data of five clinical trials in schizophrenia |

Schizo_Bin | Data of a clinical trial in Schizophrenia (with binary... |

Schizo_BinCont | Data of a clinical trial in schizophrenia, with binary and... |

Schizo_PANSS | Longitudinal PANSS data of five clinical trials in... |

Sim.Data.Counterfactuals | Simulate a dataset that contains counterfactuals |

Sim.Data.CounterfactualsBinBin | Simulate a dataset that contains counterfactuals for binary... |

Sim.Data.MTS | Simulates a dataset that can be used to assess surrogacy in... |

Sim.Data.STS | Simulates a dataset that can be used to assess surrogacy in... |

Sim.Data.STSBinBin | Simulates a dataset that can be used to assess surrogacy in... |

Single.Trial.RE.AA | Conducts a surrogacy analysis based on the single-trial... |

SPP.BinBin | Evaluate the surrogate predictive function (SPF) in the... |

SPP.BinCont | Evaluate the surrogate predictive function (SPF) in the... |

summary.gen | Summary |

SurvSurv | Assess surrogacy for two survival endpoints based on... |

Test.Mono | Test whether the data are compatible with monotonicity for S... |

TrialLevelIT | Estimates trial-level surrogacy in the information-theoretic... |

TrialLevelMA | Estimates trial-level surrogacy in the meta-analytic... |

TwoStageSurvSurv | Assess trial-level surrogacy for two survival endpoints using... |

UnifixedContCont | Fits univariate fixed-effect models to assess surrogacy in... |

UnimixedContCont | Fits univariate mixed-effect models to assess surrogacy in... |

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