Schizo_Bin: Data of a clinical trial in Schizophrenia (with binary...
In Surrogate: Evaluation of Surrogate Endpoints in Clinical Trials
Schizo_Bin R Documentation
Data of a clinical trial in Schizophrenia (with binary outcomes).
Description
These are the data of a clinical trial in Schizophrenia (a subset of the dataset Schizo_Bin, study 1 where the patients were administered 10 mg. of haloperidol or 8 mg. of risperidone). A total of 454 patients were treated by 117 investigators (psychiatrists). Patients' schizophrenia symptoms at baseline and at the end of the study (after 8 weeks) were measured using the PANSS and BPRS.
The variables BPRS_Bin and PANSS_Bin are binary outcomes that indicate whether clinically meaningful change had occurred (1 = a reduction of 20% or higher in the PANSS/BPRS scores at the last measurement compared to baseline; 0 = no such reduction; Leucht et al., 2005; Kay et al., 1988).
Usage
data(Schizo_Bin)
Format
A data.frame with 454 observations on 5 variables.
IdThe patient ID.
InvestIThe ID of the investigator (psychiatrist) who treated the patient.
TreatThe treatment indicator, coded as -1 = control treatment (10 mg. haloperidol) and 1 = experimental treatment (8 mg. risperidone).
PANSS_BinThe dichotomized change in the PANSS score (1 = a
reduction of 20% or more in the PANSS score, 0=otherwise)
BPRS_BinThe dichotomized change in the BPRS score (1 = a
reduction of 20% or more in the BPRS score, 0=otherwise)
CGI_BinThe sichtomized change in the CGI score, coded as 1 = a change of more than 3 points on the original scale (score at the end of the treatment relative to score at the beginning of the treatment), 0 = otherwise.
References
Kay, S.R., Opler, L.A., & Lindenmayer, J.P. (1988). Reliability and validity of the Positive and Negative Syndrome Scale for schizophrenics. Psychiatric Research, 23, 99-110.
Leucht, S., et al. (2005). Clinical implications of Brief Psychiatric Rating Scale scores. The British Journal of Psychiarty, 187, 366-371.
Surrogate documentation built on June 22, 2024, 9:16 a.m.
R Package Documentation
Browse R Packages
We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
| Schizo_Bin | R Documentation |
Data of a clinical trial in Schizophrenia (with binary outcomes).
Description
These are the data of a clinical trial in Schizophrenia (a subset of the dataset Schizo_Bin, study 1 where the patients were administered 10 mg. of haloperidol or 8 mg. of risperidone). A total of 454 patients were treated by 117 investigators (psychiatrists). Patients' schizophrenia symptoms at baseline and at the end of the study (after 8 weeks) were measured using the PANSS and BPRS.
The variables BPRS_Bin and PANSS_Bin are binary outcomes that indicate whether clinically meaningful change had occurred (1 = a reduction of 20% or higher in the PANSS/BPRS scores at the last measurement compared to baseline; 0 = no such reduction; Leucht et al., 2005; Kay et al., 1988).
Usage
data(Schizo_Bin)Format
A data.frame with 454 observations on 5 variables.
IdThe patient ID.
InvestIThe ID of the investigator (psychiatrist) who treated the patient.
TreatThe treatment indicator, coded as
-1= control treatment (10 mg. haloperidol) and1= experimental treatment (8 mg. risperidone).PANSS_BinThe dichotomized change in the PANSS score (1 = a reduction of
20% or more in the PANSS score, 0=otherwise)BPRS_BinThe dichotomized change in the BPRS score (1 = a reduction of
20% or more in the BPRS score, 0=otherwise)CGI_BinThe sichtomized change in the CGI score, coded as
1= a change of more than3points on the original scale (score at the end of the treatment relative to score at the beginning of the treatment),0= otherwise.
References
Kay, S.R., Opler, L.A., & Lindenmayer, J.P. (1988). Reliability and validity of the Positive and Negative Syndrome Scale for schizophrenics. Psychiatric Research, 23, 99-110.
Leucht, S., et al. (2005). Clinical implications of Brief Psychiatric Rating Scale scores. The British Journal of Psychiarty, 187, 366-371.
R Package Documentation
Browse R Packages
We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
Embedding an R snippet on your website
Add the following code to your website.
For more information on customizing the embed code, read Embedding Snippets.