Ovarian: The Ovarian dataset

In Surrogate: Evaluation of Surrogate Endpoints in Clinical Trials

The Ovarian dataset

Description

This dataset combines the data that were collected in four double-blind randomized clinical trials in advanced ovarian cancer (Ovarian Cancer Meta-Analysis Project, 1991). In these trials, the objective was to examine the efficacy of cyclophosphamide plus cisplatin (CP) versus cyclophosphamide plus adriamycin plus cisplatin (CAP) to treat advanced ovarian cancer.

Usage

data("Ovarian")

Format

A data frame with 1192 observations on the following 7 variables.

Patient

The ID number of a patient.

Center

The center in which a patient was treated.

Treat

The treatment indicator, coded as 0=CP (active control) and 1=CAP (experimental treatment).

Pfs

Progression-free survival (the candidate surrogate).

PfsInd

Censoring indicator for progression-free survival.

Surv

Survival time (the true endpoint).

SurvInd

Censoring indicator for survival time.

References

Ovarian Cancer Meta-Analysis Project (1991). Cclophosphamide plus cisplatin plus adriamycin versus cyclophosphamide, doxorubicin, and cisplatin chemotherapy of ovarian carcinoma: a meta-analysis. Classic papers and current comments, 3, 237-234.

Examples

data(Ovarian)
str(Ovarian)
head(Ovarian)

Surrogate documentation built on June 8, 2025, 1:09 p.m.