Schizo_PANSS: Longitudinal PANSS data of five clinical trials in...

Schizo_PANSSR Documentation

Longitudinal PANSS data of five clinical trials in schizophrenia

Description

These are the longitudinal PANSS data of five clinical trial in schizophrenia. A total of 2151 patients were treated by 198 investiagators (psychiatrists). There were two treatment conditions (risperidone and control). Patients' schizophrenic symptoms were measured using the PANSS at different time moments following start of the treatment. The variables Week1-Week8 express the change scores over time using the raw (semi-continuous) PANSS scores. The variables Week1_bin - Week8_bin are binary indicators of a 20% or higher reduction in PANSS score versus baseline. The latter corresponds to a commonly accepted criterion for defining a clinically meaningful response (Kay et al., 1988).

Usage

data(Schizo_PANSS)

Format

A data.frame with 2151 observations on 6 variables.

Id

The patient ID.

InvestID

The ID of the investigator (psychiatrist) who treated the patient.

Treat

The treatment indicator, coded as -1 = placebo and 1 = Risperidone.

Week1

The change in the PANSS score 1 week after starting the treatment (= score at the end of the treatment - score at 1 week after starting the treatment).

Week2

The change in the PANSS score 2 weeks after starting the treatment.

Week4

The change in the PANSS score 4 weeks after starting the treatment.

Week6

The change in the PANSS score 6 weeks after starting the treatment.

Week8

The change in the PANSS score 8 weeks after starting the treatment.

Week1_bin

The dichotomized change in the PANSS score 1 week after starting the treatment (1=a 20% or higher reduction in PANSS score versus baseline, 0=otherwise).

Week2_bin

The dichotomized change in the PANSS score 2 weeks after starting the treatment.

Week4_bin

The dichotomized change in the PANSS score 4 weeks after starting the treatment.

Week6_bin

The dichotomized change in the PANSS score 6 weeks after starting the treatment.

Week8_bin

The dichotomized change in the PANSS score 8 weeks after starting the treatment.

References

Kay, S.R., Opler, L.A., & Lindenmayer, J.P. (1988). Reliability and validity of the Positive and Negative Syndrome Scale for schizophrenics. Psychiatric Research, 23, 99-110.


Surrogate documentation built on June 22, 2024, 9:16 a.m.