plot.TrialLevelIT: Provides a plots of trial-level surrogacy in the...

In Surrogate: Evaluation of Surrogate Endpoints in Clinical Trials

Provides a plots of trial-level surrogacy in the information-theoretic framework based on the output of the TrialLevelIT() function

Description

Produces a plot that provides a graphical representation of trial-level surrogacy based on the output of the TrialLevelIT() function (information-theoretic framework).

Usage

## S3 method for class 'TrialLevelIT'
plot(x, Xlab.Trial, 
Ylab.Trial, Main.Trial, Par=par(oma=c(0, 0, 0, 0), 
mar=c(5.1, 4.1, 4.1, 2.1)), ...)

Arguments

x	An object of class TrialLevelIT.
Xlab.Trial	The legend of the X-axis of the plot that depicts trial-level surrogacy. Default "Treatment effect on the surrogate endpoint (\alpha_{i})".
Ylab.Trial	The legend of the Y-axis of the plot that depicts trial-level surrogacy. Default "Treatment effect on the true endpoint (\beta_{i})".
Main.Trial	The title of the plot that depicts trial-level surrogacy. Default "Trial-level surrogacy".
Par	Graphical parameters for the plot. Default par(oma=c(0, 0, 0, 0), mar=c(5.1, 4.1, 4.1, 2.1)).
...	Extra graphical parameters to be passed to plot().

Author(s)

Wim Van der Elst, Ariel Alonso, & Geert Molenberghs

References

Buyse, M., Molenberghs, G., Burzykowski, T., Renard, D., & Geys, H. (2000). The validation of surrogate endpoints in meta-analysis of randomized experiments. Biostatistics, 1, 49-67.

See Also

UnifixedContCont, BifixedContCont, UnifixedContCont, BimixedContCont, TrialLevelIT

Examples

# Generate vector treatment effects on S
set.seed(seed = 1)
Alpha.Vector <- seq(from = 5, to = 10, by=.1) + runif(min = -.5, max = .5, n = 51)

# Generate vector treatment effects on T
set.seed(seed=2)
Beta.Vector <- (Alpha.Vector * 3) + runif(min = -5, max = 5, n = 51)

# Apply the function to estimate R^2_{h.t}
Fit <- TrialLevelIT(Alpha.Vector=Alpha.Vector,
Beta.Vector=Beta.Vector, N.Trial=50, Model="Reduced")

# Plot the results
plot(Fit)

Surrogate documentation built on Sept. 25, 2023, 5:07 p.m.