TER.deesc.A.B: Find the bootstrap distribution

In TERAplusB: Test for A+B Traditional Escalation Rule

Description

TER.deesc.A.B finds all possible combinations of A+B design with specific dose-toxicity relations.

Usage

 TER.deesc.A.B(Dose,Prob.Dose,A,B,C,D,E)

Arguments

Dose	Dose levels
Prob.Dose	True Probability of toxicity
A	Number of patients in each level
B	Number of added patients
C	Cutoff point 1
D	Cutoff point 2
E	Cutoff point 3

Value

tot.list	All possible combinations of 1+B design
Prob.result	Exact distribution of MTD
E.toxrate	Expected toxicity rate
E.n	Expected number of patients
E.time	Expected number of periods

References

Adaptive Design Methods in Clinical Trials - Chow and Chung

Examples

     library(TERAplusB)
     TER.deesc.A.B(c("D1","D2"),c(0.2,0.7),A=3,B=3,C=1,D=2,E=2)

TERAplusB documentation built on May 1, 2019, 9:19 p.m.