acodata: A dataset from the STEP trial to study the interactions...

In TwoPhaseInd: Estimate Gene-Treatment Interaction Exploiting Randomization

A dataset from the STEP trial to study the interactions between gene and vaccine on HIV infection

Description

A dataset from the STEP trial to study the interactions between gene and vaccine on HIV infection

Usage

data("acodata")

Format

A data frame with 907 observations on the following 14 variables.

vacc1_evinf

the time to HIV infection, a numeric vector

f_evinf

the indicator variable for HIV infection, a numeric vector

subcoh

the indicator of whether the participant was selected into the sub-cohort for genotyping, a logical vector

ptid

patricipant identifier, a numeric vector

f_treat

vaccine assignment variable, a numeric vector

fcgr2a.3

the genotype of Fcr receptor FcrRIIIa, the biomarker of interest here, a numeric vector

f_agele30

a numeric vector

f_hsv_2

a numeric vector

f_ad5gt18

a numeric vector

f_crcm

a numeric vector

any_drug

a numeric vector

num_male_part_cat

a numeric vector

uias

a numeric vector

uras

a numeric vector

Details

A dataset from the STEP trial to study the interactions between gene and vaccine on HIV infection

References

S. P. Buchbinder, D. V. Mehrotra, and D. Ann et al. Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial. Lancet. 372(9653):1881-1893, 2008.

J. P. Pandey, A. M. Namboodiri, and S. Bu et l. Immunoglobulin genes and the acquisition of HIV infection in a randomized trial of recombinant adenovirus HIV vaccine. Virology, 441:70-74, 2013.

Examples

data(acodata)
## maybe str(acodata)

TwoPhaseInd documentation built on March 18, 2022, 7:52 p.m.