# Weighted Cumulative Exposure Models

### Description

Fit proportional hazards models with a weighted cumulative exposure, based on a weight function estimated from cubic regression b-splines. This implementation of WCE assumes that the dataset is in the interval format with one line per unit of time.

### Details

Package: | wce |

Type: | Package |

Version: | 1.0 |

Date: | 2015-01-09 |

License: | GPL-2 |

### Author(s)

Authors: Marie-Pierre Sylvestre <marie-pierre.sylvestre@umontreal.ca>, Marie-Eve Beauchamp <marie-eve.beauchamp@clinepi.mcgill.ca>, Ryan Patrick Kyle <ryan.kyle@mail.mcgill.ca>, Michal Abrahamowicz <michal.abrahamowicz@mcgill.ca>

Maintainer: Marie-Pierre Sylvestre <marie-pierre.sylvestre@umontreal.ca>

### References

Sylvestre MP, Abrahamowicz M. Flexible modeling of the cumulative effects of time-dependent exposures on the hazard. Stat Med. 2009;28(27):3437-53. Abrahamowicz M, Beauchamp M-E, Sylvestre M-P. Comparison of alternative models for linking drug exposure with adverse effects. Stat Med. 2012;31(11-12):1014-1030.

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