adoptr: Adaptive Optimal Two-Stage Designs in R

Optimize one or two-arm, two-stage designs for clinical trials with respect to several pre-implemented objective criteria or implement custom objectives. Optimization under uncertainty and conditional (given stage-one outcome) constraints are supported. See Pilz M, Kunzmann K, Herrmann C, Rauch G, Kieser M. A variational approach to optimal two-stage designs. Statistics in Medicine. 2019;38(21):4159–4171. <doi:10.1002/sim.8291> for details.

Package details

AuthorKevin Kunzmann [aut, cre], Maximilian Pilz [aut]
MaintainerKevin Kunzmann <>
LicenseMIT + file LICENSE
Package repositoryView on CRAN
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adoptr documentation built on Jan. 9, 2020, 5:10 p.m.