Optimize one or two-arm, two-stage designs for clinical trials with respect to several pre-implemented objective criteria or implement custom objectives. Optimization under uncertainty and conditional (given stage-one outcome) constraints are supported. See Pilz M, Kunzmann K, Herrmann C, Rauch G, Kieser M. A variational approach to optimal two-stage designs. Statistics in Medicine. 2019;1–13. <doi:10.1002/sim.8291> for details.
|Author||Kevin Kunzmann [aut, cre], Maximilian Pilz [aut]|
|Maintainer||Kevin Kunzmann <[email protected]>|
|License||MIT + file LICENSE|
|Package repository||View on CRAN|
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