GroupSequentialDesign-class: Group-sequential two-stage designs

In adoptr: Adaptive Optimal Two-Stage Designs in R

Description

Group-sequential designs are a sub-class of the TwoStageDesign class with constant stage-two sample size. See TwoStageDesign for slot details. Any group-sequential design can be converted to a fully flexible TwoStageDesign (see examples section).

Usage

GroupSequentialDesign(n1, c1f, c1e, n2_pivots, c2_pivots, order = NULL, ...)

## S4 method for signature 'GroupSequentialDesign'
TwoStageDesign(n1, ...)

Arguments

n1	stage one sample size or GroupSequentialDesign object to convert (overloaded from TwoStageDesign)
c1f	early futility stopping boundary
c1e	early efficacy stopping boundary
n2_pivots	numeric of length one, stage-two sample size
c2_pivots	numeric vector, stage-two critical values on the integration pivot points
order	of the Gaussian uadrature rule to use for integration, set to length(c2_pivots) if NULL, otherwise first value of c2_pivots is repeated 'order'-times.
...	further optional arguments

See Also

TwoStageDesign for superclass and inherited methods

Examples

design <- GroupSequentialDesign(25, 0, 2, 25, c(1, 1.5, 2.5))
summary(design)

TwoStageDesign(design)

adoptr documentation built on June 28, 2021, 5:11 p.m.