convert_nonmem: Convert NONMEM model to R syntax

In amp.sim: Flexible Simulation Utilities for Pharmacometric Modeling

Convert NONMEM model to R syntax

Description

This function converts a NONMEM model to syntax useable in R simulations. Currently deSolve, rxode2 (nonmem2rx) and mrgsolve are available syntaxes to use Additionally a code to control the simulations is created to directly test the simulations

Usage

convert_nonmem(
  model,
  out,
  ext = NULL,
  mod_return = NULL,
  type_return = "mrgsolve",
  overwrite = FALSE,
  control = "file",
  verbose = TRUE
)

Arguments

model	character with the model file to be read in and converted
out	character with the name of the output file without a file extension
ext	character with the name of the NONMEM ext file (if not provided estimates are read directly from control stream)
mod_return	a character vector indicating which items should be returned from the model function. For more information see details
type_return	character indicating the type of model that should be created. Currently "deSolve", "rxode2", "nonmem2rx" and "mrgsolve" are accepted
overwrite	logical indicating if the output model should be overwritten
control	character indicating how the model control code should be returned. Currently "file", "console", "string", "script" and "model" (only for rxode2/DeSolve) are accepted
verbose	logical indicating if additional information is written to the console

Details

For the mod_return argument, the additional variables are added to the output in case the type_return is either mrgsolve or deSolve.

Value

a converted file is generated and a message is returned

Author(s)

Richard Hooijmaijers

Examples

mod  <- system.file("example_models","PK.1CMT.ORAL.mod", package = "amp.sim")
outf <- tempfile()

convert_nonmem(mod, outf, verbose = FALSE)
readLines(paste0(outf,".cpp")) |> head(n=15) |> cat(sep="\n")

convert_nonmem(mod, outf, verbose = FALSE, type_return = "nonmem2rx") |> suppressMessages()
readLines(paste0(outf,".r")) |> head(n=15) |> cat(sep="\n")

amp.sim documentation built on May 7, 2026, 5:08 p.m.