simdata: Create a simulation dataset for NONMEM simulation

In amp.sim: Flexible Simulation Utilities for Pharmacometric Modeling

Create a simulation dataset for NONMEM simulation

Description

This function creates a simulation dataset including information for dosing and sampling. The function is setup to return a data frame to be used within NONMEM or other frameworks

Usage

simdata(time, dosetime, doseheight, addl, ii, rate = NA, numid = 5, ...)

Arguments

time	a vector with all sampling times to be used
dosetime	a vector with the different dosing times
doseheight	a vector with the different dosing heights (to be added to AMT)
addl	a vector with the additional dose levels (must be same length as doseheight)
ii	a vector with the interdose interval (must be same length as doseheight)
rate	a vector with the dosing rate (must be same length as doseheight)
numid	a vector with the number of IDs to be created
...	additional variables to be added to the resulting dataset

Value

a dataframe that can be used for NONMEM simulations

Author(s)

Richard Hooijmaijers

Examples

# Include additional variables
sim1 <- simdata(seq(0,24,1),0.5,100,10,12,NA,2, WEIGHT=70, ETA=0)

# unequal dosing scheme
sim2 <- simdata(seq(0,24,1), dosetime = c(0.5,1), doseheight = c(100,200),
                addl = c(10,5), ii = c(12,24), numid = 2)

# Directly create a sequence of different dose levels
sim3 <- lapply(seq(25,60,5),function(x){
  simdata(time=1:12,dosetime=0,doseheight=x,addl=139,ii=120,rate=0,numid=10)
}) 
sim3 <- do.call(rbind,sim3)

amp.sim documentation built on May 7, 2026, 5:08 p.m.