split_sim: Split a large NONMEM simulation in chunks

In amp.sim: Flexible Simulation Utilities for Pharmacometric Modeling

Split a large NONMEM simulation in chunks

Description

This function splits a large simulation dataset and accompanying model in chunks to prevent memory problems within the simulation or to enable simulating over multiple cores

Usage

split_sim(data, model, locout, splitby = "ID", numout = 4)

Arguments

data	character string for input dataset or a dataframe with the simulation data (see details)
model	character string for the simulation model
locout	character string for the location of the split input dataset and models
splitby	character string with the variable in the data to be split on (if this is not ID it could lead to unexpected results)
numout	the number of 'equal length' outputs to be created.

Details

In general the data can be a character string defining the input dataset (csv file) or a dataframe it is proposed to use a dataframe as in many cases the splitting should take place for a large problem. In case a dataframe is used (e.g. from loading an Rdata object) it is not necessary to import a huge csv file.

Value

split CSV and models files are written to disk

Author(s)

Richard Hooijmaijers

Examples

nmmod   <- system.file("example_models","PK.1CMT.ORAL.mod", package = "amp.sim")
dat     <- simdata(0:24, dosetime = 0, doseheight = 10, addl = 2, ii = 24, 
                   numid = 50, STHETA1= 1, STHETA2 = 2, STHETA3 = 1,
                   SETA1 = 0, SETA2 = 0)
tmp_out <- tempfile(fileext = ".csv")
mod_out <- tempfile(fileext = ".mod")

write.csv(dat,file=tmp_out, na=".", quote=FALSE, row.names = FALSE)
make_nmsimmodel(nmmod, mod_out, data=tmp_out)

split_sim(data = tmp_out, model = mod_out, locout=tempdir())
list.files(tempdir(), pattern="\\.mod$")

amp.sim documentation built on May 7, 2026, 5:08 p.m.