mdose: Performs multiple dosing in case of analytical solution of...

In amp.sim: Flexible Simulation Utilities for Pharmacometric Modeling

Performs multiple dosing in case of analytical solution of model

Description

This function takes a function that defines a model in analytical solution and performs multiple dosing for it

Usage

mdose(Dose, tau, ndose, t, func, ...)

Arguments

Dose	numeric vector with the dosing height
tau	numeric vector with the tau of dosing
ndose	numeric vector with the number of doses
t	numeric vector with the time-points that should be outputted
func	name of the function for which multiple dosing should be applied
...	arguments for func

Details

This function will create a list that can be used to perform superposition which is necessary in case of an analytical solution in a multiple dose setting. The function will check if there is an overlap in arguments and will use the arguments given to mdose for the function given in func if applicable (e.g. it is likely that func has an argument for Dose, in this case it will use the Dose argument provide in mdose) The function can have any number of arguments that can be passed using "...". However there should at least be an argument t which is the time vector for which simulations are necessary.

Value

a data frame with the superimposed results

Author(s)

Richard Hooijmaijers

Examples

ana1CMTiv <- function(Dose,pars,t){
  Dose * pars['C'] * exp(-pars['L']*t)
}
res <- mdose(10, tau = 24, ndose = 5, t = 0:240, 
             func = ana1CMTiv, pars = c(L=.01,C=5))
plot(res$time,res$y, type="l")

amp.sim documentation built on May 7, 2026, 5:08 p.m.