Description Usage Arguments Details Value Author(s) References See Also Examples

Batch effects are removed using a two-stage regression approach.

1 |

`Y` |
A matrix with |

`b` |
A vector of class factor with the element in position |

`covariates` |
An object of class data.frame where each column corresponds to a quantitative variable (of class numeric) or a qualitative variable (of class factor). |

In this implementation NA values are not allowed.

A matrix of adjusted data with *n* rows and *g* columns.

Marco Giordan

M. Giordan. February 2013. A Two-Stage Procedure for the Removal of Batch Effects in Microarray Studies. *Statistics in Biosciences*.

`ber_bg`

, `combat_np`

, `combat_p`

,`mean_centering`

, `standardization`

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