brk_toxFun: Functions for Toxicokinetic-Toxidynamic (TKTD) models
In briskaR: Biological Risk Assessment

Functions for Toxicokinetic-Toxidynamic (TKTD) models

ODE solver applied to IT-GUTS model

ODE solver applied to SD-GUTS model

brk_toxFun_damage1(exposure, kin, kout)

brk_toxFun_survival1(damage, alpha1, alpha2, alpha3)

brk_toxFun_survival2(damage, LC50, slope)

brk_survIT(time, Cw, listParameters)

brk_survSD(time, Cw, listParameters)

`exposure`	exposure level of individual
`kin`	parameter describing the intake rate of the element
`kout`	parameter describing the excretion rate of the element
`damage`	damage level on which the survival model is going to be applied
`alpha1`	parameter describing the natural background death mortality rate
`alpha2`	parameter describing the killing rate of the element on individual
`alpha3`	exponential parameter describing the killing rate of the element on individual
`LC50`	parameter describing the lethal concentration for 50% of the population
`slope`	parameter describing the slope of the curve
`time`	vector of time of the exposure profile
`Cw`	vector of concentration of the exposure profile
`listParameters`	A list of parameter for the SD model