Functions for Toxicokinetic-Toxidynamic (TKTD) models
ODE solver applied to IT-GUTS model
ODE solver applied to SD-GUTS model
1 2 3 4 5 6 7 8 9 | brk_toxFun_damage1(exposure, kin, kout)
brk_toxFun_survival1(damage, alpha1, alpha2, alpha3)
brk_toxFun_survival2(damage, LC50, slope)
brk_survIT(time, Cw, listParameters)
brk_survSD(time, Cw, listParameters)
|
exposure |
exposure level of individual |
kin |
parameter describing the intake rate of the element |
kout |
parameter describing the excretion rate of the element |
damage |
damage level on which the survival model is going to be applied |
alpha1 |
parameter describing the natural background death mortality rate |
alpha2 |
parameter describing the killing rate of the element on individual |
alpha3 |
exponential parameter describing the killing rate of the element on individual |
LC50 |
parameter describing the lethal concentration for 50% of the population |
slope |
parameter describing the slope of the curve |
time |
vector of time of the exposure profile |
Cw |
vector of concentration of the exposure profile |
listParameters |
A list of parameter for the SD model |
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