Initial conditions"

In campsis: Generic PK/PD Simulation Platform Campsis

if (campsis::on_cran()) {
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library(campsis)

This vignette shows how initial conditions may be used in Campsis.

Init central compartment

Assume the following 2-compartment model is used.

model <- model_suite$nonmem$advan3_trans4

We'd like to init the central compartment to a predefined value, e.g. 1000.
This can be achieved as follows.

model <- model %>%
  add(InitialCondition(compartment = 1, rhs = "1000"))

The resulting model has now a new block [INIT] which describes the initial condition:

model

Let's now create a dataset with observations-only.

ds <- Dataset(50) %>%
  add(Observations(times = seq(0, 72, by = 0.5)))

We can now simulate this model:

results <- simulate(model = model, dataset = ds, seed = 1)
shaded_plot(results, "CONC")

campsis documentation built on Aug. 5, 2026, 9:07 a.m.